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TargetBromodomain-containing protein 4 (BRD4)
LigandBDBM220482
Substrate/Competitorn/a
Meas. Tech.Bromodomain Domain Binding Assay
pH6±n/a
Temperature298.15±n/a K
Ki 0.81±n/a nM
Commentsextracted
Citation Wang LPratt JKMcDaniel KFDai YFidanze SDHasvold LHolms JHKati WMLiu DMantei RAMcClellan WJSheppard GSWada CK Bromodomain inhibitors US Patent  US9296741 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 (BRD4)
Name:Bromodomain-containing protein 4 (BRD4)
Synonyms:Bromodomain-containing protein 4 (BRD4-BD1)
Type:Enzyme
Mol. Mass.:13496.03
Organism:Homo sapiens (Human)
Description:BD1: amino acids K57-E168 bromodomains of human BRD4
Residue:112
Sequence:
KRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLEN
NYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
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  Blast E-value cutoff:
BDBM220482
n/a
NameBDBM220482
Synonyms:US9296741, 71
TypeSmall organic molecule
Emp. Form.C24H23N3O6S
Mol. Mass.481.521
SMILESCCOC(=O)c1cc2c(cn(C)c(=O)c2[nH]1)-c1cc(NS(C)(=O)=O)ccc1Oc1ccccc1
Structure
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