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TargetBromodomain-containing protein 4 (BRD4)
LigandBDBM220580
Substrate/Competitorn/a
Meas. Tech.Bromodomain Domain Binding Assay
pH6±n/a
Temperature298.15±n/a K
Ki 0.88±n/a nM
Commentsextracted
Citation Wang LPratt JKMcDaniel KFDai YFidanze SDHasvold LHolms JHKati WMLiu DMantei RAMcClellan WJSheppard GSWada CK Bromodomain inhibitors US Patent  US9296741 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 (BRD4)
Name:Bromodomain-containing protein 4 (BRD4)
Synonyms:Bromodomain-containing protein 4 (BRD4-BD1)
Type:Enzyme
Mol. Mass.:13496.03
Organism:Homo sapiens (Human)
Description:BD1: amino acids K57-E168 bromodomains of human BRD4
Residue:112
Sequence:
KRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLEN
NYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
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BDBM220580
n/a
NameBDBM220580
Synonyms:US9296741, 169
TypeSmall organic molecule
Emp. Form.C22H24F2N2O4S
Mol. Mass.450.499
SMILESCCS(=O)(=O)c1ccc(OC2CCC(F)(F)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Structure
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