Reaction Details |
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Target | Bromodomain-containing protein 4 (BRD4) |
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Ligand | BDBM220580 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Bromodomain Domain Binding Assay |
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pH | 6±n/a |
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Temperature | 298.15±n/a K |
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Ki | 0.88±n/a nM |
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Comments | extracted |
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Citation | Wang L; Pratt JK; McDaniel KF; Dai Y; Fidanze SD; Hasvold L; Holms JH; Kati WM; Liu D; Mantei RA; McClellan WJ; Sheppard GS; Wada CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Bromodomain-containing protein 4 (BRD4) |
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Name: | Bromodomain-containing protein 4 (BRD4) |
Synonyms: | Bromodomain-containing protein 4 (BRD4-BD1) |
Type: | Enzyme |
Mol. Mass.: | 13496.03 |
Organism: | Homo sapiens (Human) |
Description: | BD1: amino acids K57-E168 bromodomains of human BRD4 |
Residue: | 112 |
Sequence: | KRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLEN
NYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
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BDBM220580 |
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n/a |
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Name | BDBM220580 |
Synonyms: | US9296741, 169 |
Type | Small organic molecule |
Emp. Form. | C22H24F2N2O4S |
Mol. Mass. | 450.499 |
SMILES | CCS(=O)(=O)c1ccc(OC2CCC(F)(F)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12 |
Structure |
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