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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [57-168] | ||
| Ligand | BDBM220614 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Bromodomain Domain Binding Assay | ||
| pH | 6±n/a | ||
| Temperature | 298.15±n/a K | ||
| Ki | 0.69±n/a nM | ||
| Comments | extracted | ||
| Citation |  Wang, L; Pratt, JK; McDaniel, KF; Dai, Y; Fidanze, SD; Hasvold, L; Holms, JH; Kati, WM; Liu, D; Mantei, RA; McClellan, WJ; Sheppard, GS; Wada, CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [57-168] | |||
| Name: | Bromodomain-containing protein 4 [57-168] | ||
| Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 57-168) | Bromodomain-containing protein 4 (BRD4-BD1) | HUNK1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 13496.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BDI: amino acids K57-E168 | ||
| Residue: | 112 | ||
| Sequence: |
| ||
| BDBM220614 | |||
| n/a | |||
| Name | BDBM220614 | ||
| Synonyms: | US9296741, 203 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N2O5S | ||
| Mol. Mass. | 430.517 | ||
| SMILES | CCS(=O)(=O)c1ccc(O[C@H]2CC[C@H](O)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12 |wU:10.9,wD:13.13,(5.29,1.39,;6.06,2.73,;5.29,4.06,;4.52,5.39,;6.62,4.83,;3.95,3.29,;2.62,4.06,;1.29,3.29,;1.29,1.75,;-.05,.98,;-1.38,1.75,;-2.71,.98,;-4.05,1.75,;-4.05,3.29,;-5.38,4.06,;-2.71,4.06,;-1.38,3.29,;2.62,.98,;3.95,1.75,;2.62,-.56,;3.95,-1.33,;3.95,-2.87,;5.29,-3.64,;2.62,-3.64,;2.62,-5.18,;1.29,-2.87,;-.18,-3.35,;-1.08,-2.1,;-.18,-.85,;1.29,-1.33,)| | ||
| Structure | 
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