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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [57-168] | ||
| Ligand | BDBM220679 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Bromodomain Domain Binding Assay | ||
| pH | 6±n/a | ||
| Temperature | 298.15±n/a K | ||
| Ki | 0.76±n/a nM | ||
| Comments | extracted | ||
| Citation |  Wang, L; Pratt, JK; McDaniel, KF; Dai, Y; Fidanze, SD; Hasvold, L; Holms, JH; Kati, WM; Liu, D; Mantei, RA; McClellan, WJ; Sheppard, GS; Wada, CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [57-168] | |||
| Name: | Bromodomain-containing protein 4 [57-168] | ||
| Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 57-168) | Bromodomain-containing protein 4 (BRD4-BD1) | HUNK1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 13496.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BDI: amino acids K57-E168 | ||
| Residue: | 112 | ||
| Sequence: |
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| BDBM220679 | |||
| n/a | |||
| Name | BDBM220679 | ||
| Synonyms: | US9296741, 268 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H30N2O5S | ||
| Mol. Mass. | 458.57 | ||
| SMILES | CCS(=O)(=O)c1ccc(OC2CCC(C)(CC2)OC)c(c1)-c1cn(C)c(=O)c2[nH]ccc12 |(5.69,1.13,;6.46,2.46,;5.69,3.8,;4.92,5.13,;7.03,4.57,;4.36,3.03,;3.03,3.8,;1.69,3.03,;1.69,1.49,;.36,.72,;-.97,1.49,;-2.31,.72,;-3.64,1.49,;-3.64,3.03,;-5.18,3.08,;-2.31,3.8,;-.97,3.03,;-4.46,4.33,;-6,4.28,;3.03,.72,;4.36,1.49,;3.03,-.82,;4.36,-1.59,;4.36,-3.13,;5.69,-3.9,;3.03,-3.9,;3.03,-5.44,;1.69,-3.13,;.23,-3.61,;-.68,-2.36,;.23,-1.12,;1.69,-1.59,)| | ||
| Structure | 
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