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TargetBromodomain-containing protein 4 (BRD4)
LigandBDBM220518
Substrate/Competitorn/a
Meas. Tech.Bromodomain Domain Binding Assay
pH6±n/a
Temperature298.15±n/a K
Ki 0.87±n/a nM
Commentsextracted
Citation Wang LPratt JKMcDaniel KFDai YFidanze SDHasvold LHolms JHKati WMLiu DMantei RAMcClellan WJSheppard GSWada CK Bromodomain inhibitors US Patent  US9296741 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 (BRD4)
Name:Bromodomain-containing protein 4 (BRD4)
Synonyms:Bromodomain-containing protein 4 (BRD4-BD2)
Type:Enzyme
Mol. Mass.:12432.37
Organism:Homo sapiens (Human)
Description:BD2: amino acids E352-M457 bromodomains of human BRD4
Residue:106
Sequence:
EQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEARE
YRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKM
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  Blast E-value cutoff:
BDBM220518
n/a
NameBDBM220518
Synonyms:US9296741, 107
TypeSmall organic molecule
Emp. Form.C21H22F3N3O5S
Mol. Mass.485.477
SMILESCn1cc(-c2cc(NS(=O)(=O)CC(F)(F)F)ccc2OC2CCCOC2)c2cc[nH]c2c1=O
Structure
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