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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [352-457] | ||
| Ligand | BDBM220671 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Bromodomain Domain Binding Assay | ||
| pH | 6±n/a | ||
| Temperature | 298.15±n/a K | ||
| Ki | 1.2±n/a nM | ||
| Comments | extracted | ||
| Citation |  Wang, L; Pratt, JK; McDaniel, KF; Dai, Y; Fidanze, SD; Hasvold, L; Holms, JH; Kati, WM; Liu, D; Mantei, RA; McClellan, WJ; Sheppard, GS; Wada, CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [352-457] | |||
| Name: | Bromodomain-containing protein 4 [352-457] | ||
| Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 352-457) | Bromodomain-containing protein 4 (BRD4-BD2) | HUNK1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 12432.37 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BDII: amino acid E352-M457 | ||
| Residue: | 106 | ||
| Sequence: |
| ||
| BDBM220671 | |||
| n/a | |||
| Name | BDBM220671 | ||
| Synonyms: | US9296741, 260 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H28N2O5S | ||
| Mol. Mass. | 444.544 | ||
| SMILES | CCS(=O)(=O)c1ccc(O[C@H]2CC[C@@H](CC2)OC)c(c1)-c1cn(C)c(=O)c2[nH]ccc12 |wU:10.9,wD:13.16,(5.73,1.29,;6.5,2.62,;5.73,3.95,;4.96,5.29,;7.07,4.72,;4.4,3.18,;3.06,3.95,;1.73,3.18,;1.73,1.64,;.4,.87,;-.94,1.64,;-2.27,.87,;-3.6,1.64,;-3.6,3.18,;-2.27,3.95,;-.94,3.18,;-4.94,3.95,;-6.27,3.18,;3.06,.87,;4.4,1.64,;3.06,-.67,;4.4,-1.44,;4.4,-2.98,;5.73,-3.75,;3.06,-3.75,;3.06,-5.29,;1.73,-2.98,;.27,-3.45,;-.64,-2.21,;.27,-.96,;1.73,-1.44,)| | ||
| Structure | 
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