Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetBromodomain-containing protein 4 (BRD4)
LigandBDBM220735
Substrate/Competitorn/a
Meas. Tech.Bromodomain Domain Binding Assay
pH6±n/a
Temperature298.15±n/a K
Ki 1.2±n/a nM
Commentsextracted
Citation Wang LPratt JKMcDaniel KFDai YFidanze SDHasvold LHolms JHKati WMLiu DMantei RAMcClellan WJSheppard GSWada CK Bromodomain inhibitors US Patent  US9296741 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 (BRD4)
Name:Bromodomain-containing protein 4 (BRD4)
Synonyms:Bromodomain-containing protein 4 (BRD4-BD2)
Type:Enzyme
Mol. Mass.:12432.37
Organism:Homo sapiens (Human)
Description:BD2: amino acids E352-M457 bromodomains of human BRD4
Residue:106
Sequence:
EQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEARE
YRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM220735
n/a
NameBDBM220735
Synonyms:US9296741, 324
TypeSmall organic molecule
Emp. Form.C23H18F2N4O4S
Mol. Mass.484.475
SMILESCCS(=O)(=O)Nc1cc(c(Oc2ccc(F)cc2F)cc1C#N)-c1cn(C)c(=O)c2[nH]ccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: