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TargetArginase-2, mitochondrial
LigandBDBM290405
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay of Arginase
pH7.4±n/a
Temperature298.15±n/a K
IC50<250±n/a nM
Commentsextracted
Citation Van Zandt, MJagdmann, GE Arginase inhibitors as therapeutics US Patent US10098902 Publication Date 10/16/2018
More Info.:Get all data from this article,  Assay Method
 
Arginase-2, mitochondrial
Name:Arginase-2, mitochondrial
Synonyms:ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:PROTEIN
Mol. Mass.:38576.93
Organism:Homo sapiens (Human)
Description:ChEMBL_978892
Residue:354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS
LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH
SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG
FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG
KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ
LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM290405
n/a
NameBDBM290405
Synonyms:(3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(3,4- dichlorobenzylamino)ethyl)pyrrolidine-3-carboxylic acid | US10098902, Example 41 | US10603330, Example 41 | US11389464, Example 41
TypeSmall organic molecule
Emp. Form.C17H26BCl2N3O4
Mol. Mass.418.123
SMILESN[C@]1(CN(CCNCc2ccc(Cl)c(Cl)c2)C[C@@H]1CCCB(O)O)C(O)=O |r|
Structure
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