| Reaction Details |
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 | Report a problem with these data |
| Target | Arginase-1 |
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| Ligand | BDBM290415 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay of Arginase |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | <250±n/a nM |
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| Comments | extracted |
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| Citation |  Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent US10098902 Publication Date 10/16/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Arginase-1 |
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| Name: | Arginase-1 |
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| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34737.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_978893 |
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| Residue: | 322 |
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| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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| BDBM290415 |
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| n/a |
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| Name | BDBM290415 |
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| Synonyms: | (3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,2,3,4- tetrahydroisoquinolin-3-yl)methyl)pyrrolidine-3-carboxylic acid | US10098902, Example 51 | US10603330, Example 51 | US11389464, Example 51 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H27BClN3O4 |
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| Mol. Mass. | 395.689 |
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| SMILES | N[C@]1(CN(CC2Cc3cc(Cl)ccc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r| |
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| Structure | 
|
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