| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Arginase-2, mitochondrial |
|---|
| Ligand | BDBM290421 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay of Arginase |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | <250±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent US10098902 Publication Date 10/16/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Arginase-2, mitochondrial |
|---|
| Name: | Arginase-2, mitochondrial |
|---|
| Synonyms: | ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 38576.93 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_978892 |
|---|
| Residue: | 354 |
|---|
| Sequence: | MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS
LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH
SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG
FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG
KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ
LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
|
|
|
|---|
| BDBM290421 |
|---|
| n/a |
|---|
| Name | BDBM290421 |
|---|
| Synonyms: | (3R,4S)-3-amino-1-(2-amino-3-phenylpropyl)-4-(3- boronopropyl)pyrrolidine-3-carboxylic acid | US10098902, Example 57 | US10603330, Example 57 | US11389464, Example 57 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H28BN3O4 |
|---|
| Mol. Mass. | 349.233 |
|---|
| SMILES | NC(CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O)Cc1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
