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TargetNuclear receptor ROR-gamma [258-518,Y502F]
LigandBDBM221236
Substrate/Competitorn/a
Meas. Tech.RORγt Reporter Assay
IC50 92±n/a nM
Citation Leonard, KABarbay, KEdwards, JPKreutter, KDKummer, DAMaharoof, UNishimura, RUrbanski, MVenkatesan, HWang, AWolin, RLWoods, CRFourie, AXue, X Heteroaryl linked quinolinyl modulators of RORγt US Patent US9303015 Publication Date 4/5/2016
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma [258-518,Y502F]
Name:Nuclear receptor ROR-gamma [258-518,Y502F]
Synonyms:NR1F3 | RORC | RORG | RORG_HUMAN | RZRG | Retinoic acid-related nuclear receptor gamma t (RORgammat)
Type:Enzyme
Mol. Mass.:30130.98
Organism:Homo sapiens (Human)
Description:Artificial LBD sequence mutated AF2 domain (Seq No: 9)
Residue:261
Sequence:
STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMW
ERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVF
FEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKR
KVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA
FPPLFKELFSTETESPVGLSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM221236
n/a
NameBDBM221236
Synonyms:US9303015, 10a | US9303015, 10b | US9303015, 10c
TypeSmall organic molecule
Emp. Form.C28H25ClN4O4
Mol. Mass.516.976
SMILESCCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1
Structure
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