Reaction Details |
| Report a problem with these data |
Target | Nuclear receptor ROR-gamma [258-518,Y502F] |
---|
Ligand | BDBM221257 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | RORγt Reporter Assay |
---|
IC50 | 88±n/a nM |
---|
Citation | Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Heteroaryl linked quinolinyl modulators of RORγt US Patent US9303015 Publication Date 4/5/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Nuclear receptor ROR-gamma [258-518,Y502F] |
---|
Name: | Nuclear receptor ROR-gamma [258-518,Y502F] |
Synonyms: | NR1F3 | RORC | RORG | RORG_HUMAN | RZRG | Retinoic acid-related nuclear receptor gamma t (RORgammat) |
Type: | Enzyme |
Mol. Mass.: | 30130.98 |
Organism: | Homo sapiens (Human) |
Description: | Artificial LBD sequence mutated AF2 domain (Seq No: 9) |
Residue: | 261 |
Sequence: | STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMW
ERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVF
FEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKR
KVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA
FPPLFKELFSTETESPVGLSK
|
|
|
BDBM221257 |
---|
n/a |
---|
Name | BDBM221257 |
Synonyms: | US9303015, 31a | US9303015, 31b | US9303015, 31c |
Type | Small organic molecule |
Emp. Form. | C30H22ClF3N6O2 |
Mol. Mass. | 590.983 |
SMILES | Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 |
Structure |
|