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TargetNuclear receptor ROR-gamma [258-518,Y502F]
LigandBDBM221257
Substrate/Competitorn/a
Meas. Tech.RORγt Reporter Assay
IC50 88±n/a nM
Citation Leonard, KABarbay, KEdwards, JPKreutter, KDKummer, DAMaharoof, UNishimura, RUrbanski, MVenkatesan, HWang, AWolin, RLWoods, CRFourie, AXue, X Heteroaryl linked quinolinyl modulators of RORγt US Patent US9303015 Publication Date 4/5/2016
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma [258-518,Y502F]
Name:Nuclear receptor ROR-gamma [258-518,Y502F]
Synonyms:NR1F3 | RORC | RORG | RORG_HUMAN | RZRG | Retinoic acid-related nuclear receptor gamma t (RORgammat)
Type:Enzyme
Mol. Mass.:30130.98
Organism:Homo sapiens (Human)
Description:Artificial LBD sequence mutated AF2 domain (Seq No: 9)
Residue:261
Sequence:
STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMW
ERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVF
FEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKR
KVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA
FPPLFKELFSTETESPVGLSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM221257
n/a
NameBDBM221257
Synonyms:US9303015, 31a | US9303015, 31b | US9303015, 31c
TypeSmall organic molecule
Emp. Form.C30H22ClF3N6O2
Mol. Mass.590.983
SMILESCn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1
Structure
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