Ki Summary

Reaction Details

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Target

Apoptosis regulator Bcl-2

Ligand

BDBM145144

Substrate/Competitor

n/a

Meas. Tech.

Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay

Temperature

298.15±n/a K

<0.010±n/a nM

Comments

extracted

Citation

Bruncko, M; Ding, H; Doherty, GA; Elmore, SW; Hasvold, L; Hexamer, L; Kunzer, AR; Mantei, RA; Park, C; Song, X; Souers, AJ; Sullivan, GM; Tao, Z; Wang, GT; Wang, L; Wang, X; Wendt, MD Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent US9303025 Publication Date 4/5/2016

More Info.:

Get all data from this article, Assay Method

Apoptosis regulator Bcl-2

Name:

Apoptosis regulator Bcl-2

Synonyms:

Type:

Homodimer or heterodimer

Mol. Mass.:

26269.11

Organism:

Homo sapiens (Human)

Description:

P10415

Residue:

239

Sequence:

MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

BDBM145144

n/a

Name

BDBM145144

Synonyms:

US8952157, 335 | US9303025, 335

Type

Small organic molecule

Emp. Form.

C51H59ClFN7O7S

Mol. Mass.

968.573

SMILES

CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC4CCC(CC4)NC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cc4cc[nH]c4cc3F)c2)=C(C1)c1ccc(Cl)cc1 |c:65,(-6.22,13.89,;-5.5,12.53,;-4.77,13.89,;-4.16,11.76,;-4.16,10.22,;-5.5,9.45,;-5.5,7.91,;-4.16,7.14,;-4.16,5.6,;-2.83,4.83,;-1.49,5.6,;-1.49,7.14,;-2.83,7.91,;-.16,4.83,;1.17,5.6,;2.51,4.83,;2.51,3.29,;3.84,2.52,;3.84,.98,;5.17,3.29,;6.51,2.52,;7.28,3.85,;5.74,1.19,;7.84,1.75,;7.84,.21,;9.17,-.56,;10.51,.21,;11.84,-.56,;11.84,-2.1,;13.18,-2.87,;13.18,-4.41,;11.84,-5.18,;10.51,-4.41,;10.51,-2.87,;11.84,-6.72,;10.51,-7.49,;9.17,-6.72,;7.84,-7.49,;7.84,-9.03,;9.17,-9.8,;10.51,-9.03,;10.51,1.75,;9.17,2.52,;11.84,2.52,;13.18,1.75,;11.84,4.06,;1.17,2.52,;1.17,.98,;-.16,.21,;-1.49,.98,;-2.83,.21,;-4.29,.69,;-5.2,-.56,;-4.29,-1.81,;-2.83,-1.33,;-1.49,-2.1,;-.16,-1.33,;1.17,-2.1,;-.16,3.29,;-6.83,10.22,;-6.83,11.76,;-8.16,9.45,;-8.16,7.91,;-9.5,7.14,;-10.83,7.91,;-12.16,7.14,;-10.83,9.45,;-9.5,10.22,)|

Structure