| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM145200 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay |
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| Temperature | 298.15±n/a K |
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| Ki | <0.010±n/a nM |
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| Comments | extracted |
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| Citation |  Bruncko, M; Ding, H; Doherty, GA; Elmore, SW; Hasvold, L; Hexamer, L; Kunzer, AR; Mantei, RA; Park, C; Song, X; Souers, AJ; Sullivan, GM; Tao, Z; Wang, GT; Wang, L; Wang, X; Wendt, MD Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent US9303025 Publication Date 4/5/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM145200 |
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| n/a |
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| Name | BDBM145200 |
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| Synonyms: | US8952157, 391 | US9303025, 391 |
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| Type | Small organic molecule |
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| Emp. Form. | C48H56Cl2F2N8O7S |
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| Mol. Mass. | 997.975 |
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| SMILES | Nc1ncc(Oc2cc(ccc2C(=O)NS(=O)(=O)c2ccc(NCC3CCOCC3)c(c2)[N+]([O-])=O)N2CCN(CC3=C(CCC4(CCN(CC4)C(CF)CF)C3)c3ccc(Cl)cc3)CC2)cc1Cl |t:43| |
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| Structure | 
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