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TargetApoptosis regulator Bcl-2
LigandBDBM145201
Substrate/Competitorn/a
Meas. Tech.Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Temperature298.15±n/a K
Ki<0.010±n/a nM
Commentsextracted
Citation Bruncko MDing HDoherty GAElmore SWHasvold LHexamer LKunzer ARMantei RAPark CSong XSouers AJSullivan GMTao ZWang GTWang LWang XWendt MD Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent  US9303025 Publication Date 4/5/2016
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM145201
n/a
NameBDBM145201
Synonyms:US8952157, 392 | US9303025, 392
TypeSmall organic molecule
Emp. Form.C48H58Cl2N8O7S
Mol. Mass.961.995
SMILESCC(C)N1CCC2(CC1)CCC(=C(CN1CCN(CC1)c1ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc(N)c(Cl)c3)c1)C2)c1ccc(Cl)cc1 |t:12|
Structure
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