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TargetCystic fibrosis transmembrane conductance regulator
LigandBDBM221946
Substrate/Competitorn/a
Meas. Tech.IonWorks Quattro Assay
IC50 11.53±n/a nM
Citation Ahmed, MAshall-Kelly, ABloomfield, GCGueritz, LMcKenna, JMcKenna, JMutton, SParmar, RSheperd, JWright, P Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel US Patent US9303035 Publication Date 4/5/2016
More Info.:Get all data from this article,  Assay Method
 
Cystic fibrosis transmembrane conductance regulator
Name:Cystic fibrosis transmembrane conductance regulator
Synonyms:cystic fibrosis transmembrane conductance regulator protein (CFTR)
Type:Protein
Mol. Mass.:125499.86
Organism:Cricetulus griseus (Chinese hamster)
Description:G3H9J3
Residue:1107
Sequence:
WTTPILKKGYRQHLELSDVYQAPSSDSADHLSEQLEREWDREQASKKNPKLIHALRRCFF
WRFIFYGILLYLGEVTKAVQPLLLGRIIASYDPDNKVERSIAIYLGIGLCLLFIVRTLLL
HPAIFGLHRIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALA
HFVWIAPLQVALLMGLLWELLQFSAFCGLGLLIILVFFQAILGKMMVKYRVELKLTKKAA
YTRFLTSSAFFFSGFFVVLLAVLPYTVLNGIILRKIFTTISFCIVLRMAVTRQLPTAVQT
WYDSIGMITKVQDFLQYQEYKILEYNLMTTDVTMENVSAFWEEGFGELLEKVQLNNDDRK
LSNDDDNPSLGHICFLENPVLKNISFKVEKGEMLAITGSTGAGKDISKFAEKDNTILGEG
GVTLSGGQRARISLARAVYKDADVYLLDSPFGYLDVLTEEQIFENCVCKLMANKTRILVT
SKMEHLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTE
TLRRFSVDDSSVTWSKTKQAFKQTGEYGEKRKSSVLSSMKKFSIGQKIPFVIEDSDEFQD
RRLSVVPESEQGETALPRSNMIPTGPAFSGGRRRQSVLDLMTHTPTQGFSNIQRTRTSIR
KISLAPQINLKDVDIYARRLSEDNAFNITEEVNEEDLKLLFIVIGAIIVVSVLQPYIFLA
TVPGLVVFILLRAYFLHTSQQLKQLESEGEGEGSTGIILTLAMNIMSTLQWAVNTSIDVD
SLMRSVSRVFKFIDLPQEESECSKIMKGLHPEEPSQVLVIENEHVKKTDTWPSRGEMVVK
DLTVTYENDTNAMLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNIQGDIQIDGVS
WNSVTLKEWRKAFGVITQKVFIFSGTFRQNLDPHGKWRDEEIWKVADEVGLKSVIEQFPG
QLNFTLVDGGYVLSHGHKQLMGLARSVLSKARILLLDEPSAHLDPITYQIIRKVLKHTFS
GCTVILCEHRIEAILDCQRFLVIEEGTVWQYNSLQALLSEKSVFQQAISPSEKMKLFQGR
HSTKQKPRSQITALKEETEEEVQETRL
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  Blast E-value cutoff:
BDBM221946
n/a
NameBDBM221946
Synonyms:US9303035, 1.14
TypeSmall organic molecule
Emp. Form.C23H20F2N4O2
Mol. Mass.422.4273
SMILESCn1c2c3C(NCCn3c(-c3ccccc3)c2c(=O)n(C)c1=O)c1cccc(F)c1F
Structure
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