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Targetcystic fibrosis transmembrane conductance regulator protein (CFTR)
LigandBDBM221970
Substrate/Competitorn/a
Meas. Tech.IonWorks Quattro Assay
IC50 0.64±n/a nM
Citation Ahmed MAshall-Kelly ABloomfield GCGueritz LMcKenna JMcKenna JMutton SParmar RSheperd JWright P Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel US Patent  US9303035 Publication Date 4/5/2016
More Info.:Get all data from this article,  Assay Method
 
cystic fibrosis transmembrane conductance regulator protein (CFTR)
Name:cystic fibrosis transmembrane conductance regulator protein (CFTR)
Synonyms:n/a
Type:Protein
Mol. Mass.:125499.86
Organism:Cricetulus griseus (Chinese hamster)
Description:G3H9J3
Residue:1107
Sequence:
WTTPILKKGYRQHLELSDVYQAPSSDSADHLSEQLEREWDREQASKKNPKLIHALRRCFF
WRFIFYGILLYLGEVTKAVQPLLLGRIIASYDPDNKVERSIAIYLGIGLCLLFIVRTLLL
HPAIFGLHRIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALA
HFVWIAPLQVALLMGLLWELLQFSAFCGLGLLIILVFFQAILGKMMVKYRVELKLTKKAA
YTRFLTSSAFFFSGFFVVLLAVLPYTVLNGIILRKIFTTISFCIVLRMAVTRQLPTAVQT
WYDSIGMITKVQDFLQYQEYKILEYNLMTTDVTMENVSAFWEEGFGELLEKVQLNNDDRK
LSNDDDNPSLGHICFLENPVLKNISFKVEKGEMLAITGSTGAGKDISKFAEKDNTILGEG
GVTLSGGQRARISLARAVYKDADVYLLDSPFGYLDVLTEEQIFENCVCKLMANKTRILVT
SKMEHLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTE
TLRRFSVDDSSVTWSKTKQAFKQTGEYGEKRKSSVLSSMKKFSIGQKIPFVIEDSDEFQD
RRLSVVPESEQGETALPRSNMIPTGPAFSGGRRRQSVLDLMTHTPTQGFSNIQRTRTSIR
KISLAPQINLKDVDIYARRLSEDNAFNITEEVNEEDLKLLFIVIGAIIVVSVLQPYIFLA
TVPGLVVFILLRAYFLHTSQQLKQLESEGEGEGSTGIILTLAMNIMSTLQWAVNTSIDVD
SLMRSVSRVFKFIDLPQEESECSKIMKGLHPEEPSQVLVIENEHVKKTDTWPSRGEMVVK
DLTVTYENDTNAMLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNIQGDIQIDGVS
WNSVTLKEWRKAFGVITQKVFIFSGTFRQNLDPHGKWRDEEIWKVADEVGLKSVIEQFPG
QLNFTLVDGGYVLSHGHKQLMGLARSVLSKARILLLDEPSAHLDPITYQIIRKVLKHTFS
GCTVILCEHRIEAILDCQRFLVIEEGTVWQYNSLQALLSEKSVFQQAISPSEKMKLFQGR
HSTKQKPRSQITALKEETEEEVQETRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM221970
n/a
NameBDBM221970
Synonyms:US9303035, 3.2
TypeSmall organic molecule
Emp. Form.C21H20ClN5O2S
Mol. Mass.441.934
SMILESCc1csc(n1)C1NCCn2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1cccc(Cl)c1
Structure
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