| Reaction Details |
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 | Report a problem with these data |
| Target | Cystic fibrosis transmembrane conductance regulator |
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| Ligand | BDBM221974 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IonWorks Quattro Assay |
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| IC50 | 8.26±n/a nM |
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| Citation |  Ahmed, M; Ashall-Kelly, A; Bloomfield, GC; Gueritz, L; McKenna, J; McKenna, J; Mutton, S; Parmar, R; Sheperd, J; Wright, P Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel US Patent US9303035 Publication Date 4/5/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cystic fibrosis transmembrane conductance regulator |
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| Name: | Cystic fibrosis transmembrane conductance regulator |
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| Synonyms: | cystic fibrosis transmembrane conductance regulator protein (CFTR) |
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| Type: | Protein |
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| Mol. Mass.: | 125499.86 |
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| Organism: | Cricetulus griseus (Chinese hamster) |
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| Description: | G3H9J3 |
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| Residue: | 1107 |
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| Sequence: | WTTPILKKGYRQHLELSDVYQAPSSDSADHLSEQLEREWDREQASKKNPKLIHALRRCFF
WRFIFYGILLYLGEVTKAVQPLLLGRIIASYDPDNKVERSIAIYLGIGLCLLFIVRTLLL
HPAIFGLHRIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALA
HFVWIAPLQVALLMGLLWELLQFSAFCGLGLLIILVFFQAILGKMMVKYRVELKLTKKAA
YTRFLTSSAFFFSGFFVVLLAVLPYTVLNGIILRKIFTTISFCIVLRMAVTRQLPTAVQT
WYDSIGMITKVQDFLQYQEYKILEYNLMTTDVTMENVSAFWEEGFGELLEKVQLNNDDRK
LSNDDDNPSLGHICFLENPVLKNISFKVEKGEMLAITGSTGAGKDISKFAEKDNTILGEG
GVTLSGGQRARISLARAVYKDADVYLLDSPFGYLDVLTEEQIFENCVCKLMANKTRILVT
SKMEHLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTE
TLRRFSVDDSSVTWSKTKQAFKQTGEYGEKRKSSVLSSMKKFSIGQKIPFVIEDSDEFQD
RRLSVVPESEQGETALPRSNMIPTGPAFSGGRRRQSVLDLMTHTPTQGFSNIQRTRTSIR
KISLAPQINLKDVDIYARRLSEDNAFNITEEVNEEDLKLLFIVIGAIIVVSVLQPYIFLA
TVPGLVVFILLRAYFLHTSQQLKQLESEGEGEGSTGIILTLAMNIMSTLQWAVNTSIDVD
SLMRSVSRVFKFIDLPQEESECSKIMKGLHPEEPSQVLVIENEHVKKTDTWPSRGEMVVK
DLTVTYENDTNAMLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNIQGDIQIDGVS
WNSVTLKEWRKAFGVITQKVFIFSGTFRQNLDPHGKWRDEEIWKVADEVGLKSVIEQFPG
QLNFTLVDGGYVLSHGHKQLMGLARSVLSKARILLLDEPSAHLDPITYQIIRKVLKHTFS
GCTVILCEHRIEAILDCQRFLVIEEGTVWQYNSLQALLSEKSVFQQAISPSEKMKLFQGR
HSTKQKPRSQITALKEETEEEVQETRL
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| BDBM221974 |
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| n/a |
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| Name | BDBM221974 |
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| Synonyms: | US9303035, 3.6 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23ClN4O3 |
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| Mol. Mass. | 438.907 |
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| SMILES | Cc1cc(C)cc(c1)-c1n2CCNC(c3ccc(Cl)o3)c2c2n(C)c(=O)n(C)c(=O)c12 |
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| Structure | 
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