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TargetAlkaline phosphatase, tissue-nonspecific isozyme
LigandBDBM222182
Substrate/Competitorn/a
Meas. Tech.Alkaline Phosphatase Inhibition Assay
pH9.8±n/a
Temperature310.15±n/a K
IC50 5.0e+2± 2e+1 nM
Commentsextracted
Citation Bhatti, HAKhatoon, MAl-Rashida, MBano, HIqbal, NZaib-Un-Nisa, nullYousuf, SKhan, KMHameed, AIqbal, J Facile dimethyl amino group triggered cyclic sulfonamides synthesis and evaluation as alkaline phosphatase inhibitors. Bioorg Chem71:10-18 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alkaline phosphatase, tissue-nonspecific isozyme
Name:Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP)
Type:Protein
Mol. Mass.:57195.60
Organism:Bos taurus (Cattle)
Description:P09487
Residue:524
Sequence:
MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDE
KARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELN
RNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIG
QAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYI
PHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
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  Blast E-value cutoff:
BDBM222182
n/a
NameBDBM222182
Synonyms:6-(Dimethylamino)-3-(4'-hydroxyphenyl)-2,3-dihydronaphtho[1,8-de][1,2]thiazine 1,1-dioxide (7d)
TypeSmall organic molecule
Emp. Form.C19H18N2O3S
Mol. Mass.354.423
SMILESCN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccc(O)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: