| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 144 [31-434] |
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| Ligand | BDBM222346 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Optical Titration Assay |
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| pH | 7±n/a |
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| Kd | 8.2e+4± 4e+3 nM |
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| Comments | extracted |
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| Citation |  Kavanagh, ME; Chenge, J; Zoufir, A; McLean, KJ; Coyne, AG; Bender, A; Munro, AW; Abell, C Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1. Biochemistry56:1559-1572 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 144 [31-434] |
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| Name: | Cytochrome P450 144 [31-434] |
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| Synonyms: | CP144_MYCTO | Cytochrome P450 144 (CYP144A1-TRV) | cyp144 |
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| Type: | Protein |
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| Mol. Mass.: | 43963.64 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | M. tuberculosis cytochrome P450 144 truncation (31-434 aa) |
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| Residue: | 404 |
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| Sequence: | MTIAKDANTFFGAESVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFS
SNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQF
TVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEG
LVENDQLVAAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVT
LFAAGGESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRN
ATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAAL
ARLEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ
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| BDBM222346 |
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| n/a |
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| Name | BDBM222346 |
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| Synonyms: | CYP144A1 ligand, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19N5O2 |
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| Mol. Mass. | 397.4293 |
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| SMILES | Oc1ccc(cc1)-c1n[nH]c(NCc2cccc3[nH]ncc23)c1-c1ccc(O)cc1 |
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| Structure | 
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