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TargetDNA polymerase catalytic subunit
LigandBDBM222909
Substrate/Competitorn/a
Meas. Tech.HCMV Polymerase LANCE TR-FRET Assay
pH7.5±n/a
IC50 65±n/a nM
Commentsextracted
Citation Fader, LLepage, OBailey, MBeaulieu, PLBilodeau, FCarson, RJGiroux, AGodbout, CMoreau, BNaud, JParisien, MPoirier, MPoirier, MSurprenant, SThibeault, C Cytomegalovirus inhibitor compounds US Patent US9315499 Publication Date 4/19/2016
More Info.:Get all data from this article,  Assay Method
 
DNA polymerase catalytic subunit
Name:DNA polymerase catalytic subunit
Synonyms:DNA polymerase | DPOL_HCMVA | HFLF2 | Human herpesvirus 5 DNA polymerase | UL54
Type:Protein
Mol. Mass.:137111.39
Organism:Human cytomegalovirus (HCMV strain AD169)
Description:P08546
Residue:1242
Sequence:
MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKH
KTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTDAVLFFDSPENVS
PRYRQHLVPSGNVLRFFGATEHGYSICVNVFGQRSYFYCEYSDTDRLREVIASVGELVPE
PRTPYAVSVTPATKTSIYGYGTRPVPDLQCVSISNWTMARKIGEYLLEQGFPVYEVRVDP
LTRLVIDRRITTFGWCSVNRYDWRQQGRASTCDIEVDCDVSDLVAVPDDSSWPRYRCLSF
DIECMSGEGGFPCAEKSDDIVIQISCVCYETGGNTAVDQGIPNGNDGRGCTSEGVIFGHS
GLHLFTIGTCGQVGPDVDVYEFPSEYELLLGFMLFFQRYAPAFVTGYNINSFDLKYILTR
LEYLYKVDSQRFCKLPTAQGGRFFLHSPAVGFKRQYAAAFPSASHNNPASTAATKVYIAG
SVVIDMYPVCMAKTNSPNYKLNTMAELYLRQRKDDLSYKDIPRCFVANAEGRAQVGRYCL
QDAVLVRDLFNTINFHYEAGAIARLAKIPLRRVIFDGQQIRIYTSLLDECACRDFILPNH
YSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGS
NSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPEVGYYNDPVAVFDFAS
LYPSIIMAHNLCYSTLLVPGGEYPVDPADVYSVTLENGVTHRFVRASVRVSVLSELLNKW
VSQRRAVRECMRECQDPVRRMLLDKEQMALKVTCNAFYGFTGVVNGMMPCLPIAASITRI
GRDMLERTARFIKDNFSEPCFLHNFFNQEDYVVGTREGDSEESSALPEGLETSSGGSNER
RVEARVIYGDTDSVFVRFRGLTPQALVARGPSLAHYVTACLFVEPVKLEFEKVFVSLMMI
CKKRYIGKVEGASGLSMKGVDLVRKTACEFVKGVTRDVLSLLFEDREVSEAAVRLSRLSL
DEVKKYGVPRGFWRILRRLVQARDDLYLHRVRVEDLVLSSVLSKDISLYRQSNLPHIAVI
KRLAARSEELPSVGDRVFYVLTAPGVRTAPQGSSDNGDSVTAGVVSRSDAIDGTDDDADG
GGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHGVPIHADKYFEQVLKAVTNV
LSPVFPGGETARKDKFLHMVLPRRLHLEPAFLPYSVKAHECC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM222909
n/a
NameBDBM222909
Synonyms:US9315499, 4020
TypeSmall organic molecule
Emp. Form.C28H29ClN6O3
Mol. Mass.533.021
SMILESCn1nccc1Cc1cnc2n(CC(=O)N3CC(C)(C)C3)c(=O)c(cc2c1)C(=O)NCc1ccc(Cl)cc1
Structure
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