| Reaction Details |
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 | Report a problem with these data |
| Target | Guanine nucleotide-binding protein subunit alpha-15/Metabotropic glutamate receptor 2 |
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| Ligand | BDBM222991 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Laser Imaging Plate Reader (FLIPR) Based Assay |
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| EC50 | 1178±n/a nM |
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| Citation |  Fiji, HD; Kelly, III, MJ; Kern, JC; Layton, ME; Pero, JE; Reif, AJ; Rossi, MA Imidazopyridin-2-one derivatives US Patent US9315518 Publication Date 4/19/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Guanine nucleotide-binding protein subunit alpha-15/Metabotropic glutamate receptor 2 |
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| Name: | Guanine nucleotide-binding protein subunit alpha-15/Metabotropic glutamate receptor 2 |
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| Synonyms: | mGluR2 and G alpha 16 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Metabotropic glutamate receptor 2 |
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| Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 95584.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14416 |
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| Residue: | 872 |
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| Sequence: | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
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| Component 2 |
| Name: | Guanine nucleotide-binding protein subunit alpha-15 |
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| Synonyms: | G-protein subunit alpha-16 | G-protein subunit alpha-16 (G alpha-16) | GNA15 | GNA15_HUMAN | GNA16 | guanine nucleotide-binding protein subunit alpha-15 |
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| Type: | Protein |
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| Mol. Mass.: | 43577.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30679 |
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| Residue: | 374 |
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| Sequence: | MARSLTWRCCPWCLTEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIK
QMRIIHGAGYSEEERKGFRPLVYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLVMSQD
PYKVTTFEKRYAAAMQWLWRDAGIRAYYERRREFHLLDSAVYYLSHLERITEEGYVPTAQ
DVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQ
CLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFQG
PKQDAEAAKRFILDMYTRMYTGCVDGPEGSKKGARSRRLFSHYTCATDTQNIRKVFKDVR
DSVLARYLDEINLL
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| BDBM222991 |
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| n/a |
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| Name | BDBM222991 |
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| Synonyms: | US9315518, 38-5 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H30N6O2 |
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| Mol. Mass. | 398.5019 |
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| SMILES | Cn1cnc(c1)C(=O)NCCCCc1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1 |
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| Structure | 
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