Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDiscoidin domain-containing receptor 2
LigandBDBM223094
Substrate/Competitorn/a
Meas. Tech.LanthaScreen Eu Kinase Activity Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 32.9±3.3 nM
Commentsextracted
Citation Liu, LHussain, MLuo, JDuan, AChen, CTu, ZZhang, J Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors. Chem Biol Drug Des89:420-427 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Discoidin domain-containing receptor 2
Name:Discoidin domain-containing receptor 2
Synonyms:DDR2 | DDR2_HUMAN | Discoidin domain receptor 2 (DDR2) | Discoidin domain-containing receptor 2 | Discoidin domain-containing receptor 2 (DDR2) | Epithelial discoidin domain-containing receptor 2 (DDR2) | NTRKR3 | TKT | TYRO10
Type:Protein
Mol. Mass.:96717.07
Organism:Homo sapiens (Human)
Description:Q16832
Residue:855
Sequence:
MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY
GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI
NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV
ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD
DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK
EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS
EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL
WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD
YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV
PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN
QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG
DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK
NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET
FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP
SFQEIHLLLLQQGDE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM223094
n/a
NameBDBM223094
Synonyms:Methyl 3-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)pyrrolidine-1-carboxylate (5a)
TypeSmall organic molecule
Emp. Form.C22H23ClN6O3S
Mol. Mass.486.974
SMILESCOC(=O)N1CCC(C1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: