| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-glucosidase MAL32 |
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| Ligand | BDBM223120 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro α-Glucosidase Inhibitory Assay |
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| pH | 6.8±n/a |
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| IC50 | 77790±1570 nM |
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| Comments | extracted |
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| Citation |  Wang, G; Wang, J; He, D; Li, X; Li, J; Peng, Z Synthesis, in vitro evaluation and molecular docking studies of novel coumarin-isatin derivatives as a-glucosidase inhibitors. Chem Biol Drug Des89:456-463 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-glucosidase MAL32 |
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| Name: | Alpha-glucosidase MAL32 |
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| Synonyms: | Alpha-glucosidase MAL32 | MAL32 | MAL32_YEAST | MAL3S | Maltase | alpha-Glucosidase (α-Glucosidase) | alpha-Glucosidase (alpha-Glu) | alpha-Glucosidase (α-Glucosidase) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 68132.36 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | Purchased from Wako Fine Chemicals Co. Ltd. |
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| Residue: | 584 |
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| Sequence: | MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCP
FYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFK
ESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASR
QVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHP
NWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSF
THVELGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADD
SPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSF
GKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFFLNESFEQGINVEQ
ESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNF
SGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
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| BDBM223120 |
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| n/a |
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| Name | BDBM223120 |
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| Synonyms: | (Z)-N'-(1-(3-fluorobenzyl)-5-methyl-2-oxoindolin-3-ylidene)-2-((2-oxo-2H-chromen-7-yl)oxy)acetohydrazide (5o) |
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| Type | Small organic molecule |
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| Emp. Form. | C27H20FN3O5 |
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| Mol. Mass. | 485.4632 |
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| SMILES | Cc1ccc2N(Cc3cccc(F)c3)C(=O)\C(=N/NC(=O)COc3ccc4ccc(=O)oc4c3)c2c1 |
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| Structure | 
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