| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 6 |
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| Ligand | BDBM223137 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Enzymatic Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | >1.00e+5±n/a nM |
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| Comments | extracted |
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| Citation |  Ji, S; Ma, S; Wang, WJ; Huang, SZ; Wang, TQ; Xiang, R; Hu, YG; Chen, Q; Li, LL; Yang, SY Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations. Chem Biol Drug Des89:585-598 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 6 |
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| Name: | Protein arginine N-methyltransferase 6 |
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| Synonyms: | ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6) |
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| Type: | Protein |
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| Mol. Mass.: | 41928.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 375 |
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| Sequence: | MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEM
IADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQA
REVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKE
GGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQG
LSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGE
SEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYK
VGDQEEKTKDFAMED
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| BDBM223137 |
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| n/a |
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| Name | BDBM223137 |
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| Synonyms: | P5i-6 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10ClN3O2 |
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| Mol. Mass. | 263.68 |
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| SMILES | NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1 |
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| Structure | 
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