Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetEnoyl-[acyl-carrier-protein] reductase [NADH]
LigandBDBM50399407
Substrate/Competitorn/a
Meas. Tech.Inhibition Kinetics Assay
pH8±0
Temperature298.15±0 K
Ki 405±2 nM
Citation Neckles, CEltschkner, SCummings, JEHirschbeck, MDaryaee, FBommineni, GRZhang, ZSpagnuolo, LYu, WDavoodi, SSlayden, RAKisker, CTonge, PJ Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase. Biochemistry56:1865-1878 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Enoyl-[acyl-carrier-protein] reductase [NADH]
Name:Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:Enoyl-ACP reductase (FabI1)
Type:Enzyme
Mol. Mass.:27824.56
Organism:Burkholderia pseudomallei
Description:Q3JG55
Residue:253
Sequence:
MRLQHKRGLIIGIANENSIAFGCARVMREQGAELALTYLNEKAEPYVRPLAQRLDSRLVV
PCDVREPGRLEDVFARIAQEWGQLDFVLHSIAYAPKEDLHRRVTDCSQAGFAMAMDVSCH
SFIRVARLAEPLMTNGGCLLTVTFYGAERAVEDYNLMGPVKAALEGSVRYLAAELGPRRI
RVHALSPGPLKTRAASGIDRFDALLERVRERTPGHRLVDIDDVGHVAAFLASDDAAALTG
NVEYIDGGYHVVG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50399407
n/a
NameBDBM50399407
Synonyms:CHEMBL2178284 | MUT056399
TypeSmall organic molecule
Emp. Form.C15H13F2NO3
Mol. Mass.293.2654
SMILESCCc1cc(O)c(Oc2ccc(cc2F)C(N)=O)cc1F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: