Reaction Details |
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Target | Enoyl-[acyl-carrier-protein] reductase [NADH] |
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Ligand | BDBM223193 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Kinetics Assay |
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pH | 8±0 |
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Temperature | 298.15±0 K |
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Ki | 44±0 nM |
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Citation | Neckles, C; Eltschkner, S; Cummings, JE; Hirschbeck, M; Daryaee, F; Bommineni, GR; Zhang, Z; Spagnuolo, L; Yu, W; Davoodi, S; Slayden, RA; Kisker, C; Tonge, PJ Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase. Biochemistry56:1865-1878 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Enoyl-[acyl-carrier-protein] reductase [NADH] |
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Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] |
Synonyms: | Enoyl-ACP reductase (FabI1) |
Type: | Enzyme |
Mol. Mass.: | 27824.56 |
Organism: | Burkholderia pseudomallei |
Description: | Q3JG55 |
Residue: | 253 |
Sequence: | MRLQHKRGLIIGIANENSIAFGCARVMREQGAELALTYLNEKAEPYVRPLAQRLDSRLVV
PCDVREPGRLEDVFARIAQEWGQLDFVLHSIAYAPKEDLHRRVTDCSQAGFAMAMDVSCH
SFIRVARLAEPLMTNGGCLLTVTFYGAERAVEDYNLMGPVKAALEGSVRYLAAELGPRRI
RVHALSPGPLKTRAASGIDRFDALLERVRERTPGHRLVDIDDVGHVAAFLASDDAAALTG
NVEYIDGGYHVVG
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BDBM223193 |
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n/a |
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Name | BDBM223193 |
Synonyms: | PT409 |
Type | Small organic molecule |
Emp. Form. | C14H13NO4 |
Mol. Mass. | 259.2573 |
SMILES | CCc1ccc(Oc2ccccc2[N+]([O-])=O)c(O)c1 |
Structure |
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