Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 [1-322] |
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Ligand | BDBM223197 |
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Substrate/Competitor | n/a |
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Meas. Tech. | PTP1B Activity Assay |
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pH | 7±0 |
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Ki | 2.7e+4±n/a nM |
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IC50 | 5.4e+4± 1e+3 nM |
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Citation | Punthasee, P; Laciak, AR; Cummings, AH; Ruddraraju, KV; Lewis, SM; Hillebrand, R; Singh, H; Tanner, JJ; Gates, KS Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor-Electrophile Conjugate. Biochemistry56:2051-2060 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 [1-322] |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 [1-322] |
Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) |
Type: | Enzyme |
Mol. Mass.: | 37368.76 |
Organism: | Homo sapiens (Human) |
Description: | Human PTP1B truncation (1-322 aa) |
Residue: | 322 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNG
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BDBM223197 |
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n/a |
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Name | BDBM223197 |
Synonyms: | 2-Bromo-N-[3'-(1,1-dioxido-4-oxo-1,2,5-thiadiazolidin-2-yl)-4'-methyl[1,1'-biphenyl]-4-yl]-acetamide (5a) |
Type | Small organic molecule |
Emp. Form. | C17H16BrN3O4S |
Mol. Mass. | 438.296 |
SMILES | Cc1ccc(cc1N1CC(=O)NS1(=O)=O)-c1ccc(NC(=O)CBr)cc1 |
Structure |
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