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TargetTyrosine-protein phosphatase non-receptor type 1 [1-322]
LigandBDBM223198
Substrate/Competitorn/a
Meas. Tech.PTP1B Activity Assay
pH7±0
Ki 3.2e+4±n/a nM
IC50 6.4e+4± 7e+3 nM
Citation Punthasee, PLaciak, ARCummings, AHRuddraraju, KVLewis, SMHillebrand, RSingh, HTanner, JJGates, KS Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor-Electrophile Conjugate. Biochemistry56:2051-2060 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein phosphatase non-receptor type 1 [1-322]
Name:Tyrosine-protein phosphatase non-receptor type 1 [1-322]
Synonyms:PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B)
Type:Enzyme
Mol. Mass.:37368.76
Organism:Homo sapiens (Human)
Description:Human PTP1B truncation (1-322 aa)
Residue:322
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNG
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  Blast E-value cutoff:
BDBM223198
n/a
NameBDBM223198
Synonyms:N-[3'-(1,1-Dioxido-4-oxo-1,2,5-thiadiazolidin-2-yl)-4'-methyl[1,1'-biphenyl]-4-yl]acetamide (5b)
TypeSmall organic molecule
Emp. Form.C17H17N3O4S
Mol. Mass.359.4
SMILESCC(=O)Nc1ccc(cc1)-c1ccc(C)c(c1)N1CC(=O)NS1(=O)=O
Structure
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