| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 [1-322] |
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| Ligand | BDBM223199 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PTP1B Activity Assay |
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| pH | 7±0 |
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| Ki | 3.85e+4±n/a nM |
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| IC50 | 7.7e+4± 9e+3 nM |
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| Citation |  Punthasee, P; Laciak, AR; Cummings, AH; Ruddraraju, KV; Lewis, SM; Hillebrand, R; Singh, H; Tanner, JJ; Gates, KS Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor-Electrophile Conjugate. Biochemistry56:2051-2060 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 [1-322] |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 [1-322] |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37368.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human PTP1B truncation (1-322 aa) |
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| Residue: | 322 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNG
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| BDBM223199 |
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| n/a |
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| Name | BDBM223199 |
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| Synonyms: | 5-(4-Methyl[1,1'-biphenyl]-3-yl)-1,2,5-thiadiazolidin-3-one 1,1-Dioxide (2b) |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14N2O3S |
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| Mol. Mass. | 302.348 |
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| SMILES | Cc1ccc(cc1N1CC(=O)NS1(=O)=O)-c1ccccc1 |
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| Structure | 
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