| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
|---|
| Ligand | BDBM223202 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PEPCK Inhibition Assay |
|---|
| Ki | 1.50e+5± 5.0e+4 nM |
|---|
| Citation |  Cui, DS; Broom, A; Mcleod, MJ; Meiering, EM; Holyoak, T Asymmetric Anchoring Is Required for Efficient O-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry56:2106-2115 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
|---|
| Name: | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
|---|
| Synonyms: | Cytosolic phosphoenolpyruvate carboxykinase (cPEPCK) | PCKGC_RAT | PEPCK-C | Pck1 | Phosphoenolpyruvate carboxykinase (PEPCK) | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | Phosphoenolpyruvate carboxylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 69414.48 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 622 |
|---|
| Sequence: | MPPQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHM
QEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEE
DFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSV
LEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSL
LGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTL
PGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNV
AETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAW
ESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKVIMHDPF
AMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWM
FGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQV
NADLPYEIERELRALKQRISQM
|
|
|
|---|
| BDBM223202 |
|---|
| n/a |
|---|
| Name | BDBM223202 |
|---|
| Synonyms: | β,γ-methyleneguanosine 5′-triphosphate | GMPPCP |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H17N5O13P3 |
|---|
| Mol. Mass. | 520.2002 |
|---|
| SMILES | Nc1nc([O-])c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)C[P+](O)(O)[O-])[C@@H](O)[C@H]3O)c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
