| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase type IV [15-340] |
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| Ligand | BDBM223208 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Molecular Docking |
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| Ki | 1351.35±29.22 nM |
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| Citation |  Jameel, E; Naz, H; Khan, P; Tarique, M; Kumar, J; Mumtazuddin, S; Ahamad, S; Islam, A; Ahmad, F; Hoda, N; Hassan, MI Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV. Chem Biol Drug Des89:741-754 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase type IV [15-340] |
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| Name: | Calcium/calmodulin-dependent protein kinase type IV [15-340] |
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| Synonyms: | CAMK | CAMK-GR | CAMK4 | CAMKIV | Calcium/calmodulin- dependent protein kinase IV (CAMKIV) | KCC4_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 39277.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PDB 2W4O used as reference |
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| Residue: | 349 |
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| Sequence: | MHHHHHHSSGVDLGTENLYFQSMSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESE
LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETP
TEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLL
YATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIIT
YILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTT
FQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLG
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| BDBM223208 |
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| n/a |
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| Name | BDBM223208 |
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| Synonyms: | 7-((6-((5-Methoxy-1H-benzo[d]imidazol-2-yl)thio)pyrimidin-4-yl)oxy)-4-methyl-2H-chromen-2-one (Molecule 5) |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16N4O4S |
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| Mol. Mass. | 432.452 |
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| SMILES | COc1ccc2[nH]c(Sc3cc(Oc4ccc5c(C)cc(=O)oc5c4)ncn3)nc2c1 |
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| Structure | 
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