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TargetCalcium/calmodulin-dependent protein kinase type IV [15-340]
LigandBDBM223209
Substrate/Competitorn/a
Meas. Tech.Molecular Docking
Ki 0.01087±0.00021 nM
Citation Jameel, E; Naz, H; Khan, P; Tarique, M; Kumar, J; Mumtazuddin, S; Ahamad, S; Islam, A; Ahmad, F; Hoda, N; Hassan, MI Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV. Chem Biol Drug Des89:741-754 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calcium/calmodulin-dependent protein kinase type IV [15-340]
Name:Calcium/calmodulin-dependent protein kinase type IV [15-340]
Synonyms:CAMK | CAMK-GR | CAMK4 | CAMKIV | Calcium/calmodulin- dependent protein kinase IV (CAMKIV) | KCC4_HUMAN
Type:Enzyme
Mol. Mass.:39277.89
Organism:Homo sapiens (Human)
Description:PDB 2W4O used as reference
Residue:349
Sequence:
MHHHHHHSSGVDLGTENLYFQSMSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESE
LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETP
TEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLL
YATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIIT
YILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTT
FQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLG
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  Blast E-value cutoff:
BDBM223209
n/a
NameBDBM223209
Synonyms:8-((6-Chloropyrimidin-4-yl)oxy)quinoline (Compound 1)
TypeSmall organic molecule
Emp. Form.C13H8ClN3O
Mol. Mass.257.675
SMILESClc1cc(Oc2cccc3cccnc23)ncn1
Structure
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