| Reaction Details |
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 | Report a problem with these data |
| Target | Ezrin |
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| Ligand | BDBM223225 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SPR Assay |
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| pH | 5.5±n/a |
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| Temperature | 298.15±n/a K |
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| Kd | 7.492e+4± 7.21e+3 nM |
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| Comments | extracted |
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| Citation |  Rox, K; Rohde, M; Chhatwal, GS; Müller, R Disorazoles Block Group A Streptococcal Invasion into Epithelial Cells Via Interference with the Host Factor Ezrin. Cell Chem Biol24:159-170 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ezrin |
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| Name: | Ezrin |
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| Synonyms: | Cytovillin | EZR | EZRI_HUMAN | VIL2 | Villin-2 | p81 |
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| Type: | Protein |
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| Mol. Mass.: | 69408.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15311 |
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| Residue: | 586 |
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| Sequence: | MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK
LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE
TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR
GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI
EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK
AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE
LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP
VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ
ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
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| BDBM223225 |
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| n/a |
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| Name | BDBM223225 |
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| Synonyms: | Disorazole Z |
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| Type | Small organic molecule |
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| Emp. Form. | C40H46N2O12 |
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| Mol. Mass. | 746.7994 |
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| SMILES | COC(=O)C(C)([C@@H](O)\C=C\C)[C@@H]1C\C=C/C=C/C=C/c2nc(co2)C(=O)O[C@@H](C\C=C/C=C/C=C/c2nc(co2)C(=O)O1)C(C)([C@@H](O)\C=C\C)C(=O)OC |r,c:13,30,t:15,17,32,34| |
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| Structure | 
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