| Reaction Details |
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 | Report a problem with these data |
| Target | Leukotriene C4 synthase |
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| Ligand | BDBM223281 |
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| Substrate/Competitor | LTC4 |
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| Meas. Tech. | In Vitro hLTC4 Synthase Enzyme Assay (Test A) |
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| pH | 7.8±n/a |
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| IC50 | 17±n/a nM |
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| Comments | extracted |
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| Citation |  Ronn, R; Lindh, CJ; Ringberg, E; Andersson, HB; Nilsson, P; Schaal, WR; Rosenschold, MM; Nikitidis, A; Nikitidis, G; Johannesson, P; Tyrcha, C Compounds and uses US Patent US20160326143 Publication Date 11/10/2016 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Leukotriene C4 synthase |
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| Name: | Leukotriene C4 synthase |
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| Synonyms: | LTC4 synthase | LTC4S | LTC4S_HUMAN | Leukotriene-C(4) synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 16575.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_961179 |
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| Residue: | 150 |
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| Sequence: | MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF
PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA
LAALGLLAHFLPAALRAALLGRLRTLLPWA
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| BDBM223281 |
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| LTC4 |
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| Name | BDBM223281 |
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| Synonyms: | 2-(5-((Cyclopropylmethyl)(naphthalen-1-yl)amino)-4-methoxypyrimidine-2-carbonyl)cyclopropanecarboxylic acid | US20160326143, 56 | US9657001, 56 |
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| Type | Small Organic Molecule |
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| Emp. Form. | C24H22ClN3O4 |
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| Mol. Mass. | 451.902 |
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| SMILES | COc1nc(ncc1N(CC1CC1)c1ccc(Cl)c2ccccc12)C(=O)C1CC1C(O)=O |
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| Structure | 
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