| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-5 |
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| Ligand | BDBM85511 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Caspase Catalytic Activity Assay |
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| pH | 7.4±n/a |
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| IC50 | 1.0e+3± 1e+2 nM |
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| Comments | extracted |
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| Citation |  Smith, CE; Soti, S; Jones, TA; Nakagawa, A; Xue, D; Yin, H Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol24:281-292 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-5 |
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| Name: | Caspase-5 |
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| Synonyms: | CASP-5 | CASP5 | CASP5_HUMAN | Caspase 5 | Caspase-5 subunit p10 | Caspase-5 subunit p20 | ICE(rel)-III | ICH-3 protease | ICH3 | Protease ICH-3 | Protease TY | TY protease |
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| Type: | Enzyme |
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| Mol. Mass.: | 49760.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51878 |
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| Residue: | 434 |
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| Sequence: | MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK
KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
RATLTRDFYLFPGN
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| BDBM85511 |
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| n/a |
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| Name | BDBM85511 |
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| Synonyms: | CAS_74103-07-4 | KETOROLAC | Ketorolac tris salt | Toradol |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13NO3 |
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| Mol. Mass. | 255.2686 |
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| SMILES | OC(=O)C1CCn2c1ccc2C(=O)c1ccccc1 |
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| Structure | 
|
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