| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-4 |
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| Ligand | BDBM223313 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Caspase Catalytic Activity Assay |
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| pH | 7.4±n/a |
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| IC50 | 3.8e+2± 1e+1 nM |
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| Comments | extracted |
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| Citation |  Smith, CE; Soti, S; Jones, TA; Nakagawa, A; Xue, D; Yin, H Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol24:281-292 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-4 |
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| Name: | Caspase-4 |
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| Synonyms: | CASP-4 | CASP4 | CASP4_HUMAN | Caspase 4 | Caspase-4 subunit 1 | Caspase-4 subunit 2 | ICE(rel)-II | ICH-2 protease | ICH2 | TX protease |
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| Type: | Enzyme |
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| Mol. Mass.: | 43257.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49662 |
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| Residue: | 377 |
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| Sequence: | MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE
RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN
RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP
TIERLSMTRYFYLFPGN
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| BDBM223313 |
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| n/a |
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| Name | BDBM223313 |
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| Synonyms: | Tiaprofenic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12O3S |
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| Mol. Mass. | 260.308 |
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| SMILES | CC(C(O)=O)c1ccc(s1)C(=O)c1ccccc1 |
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| Structure | 
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