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TargetBeta-secretase 1 (BACE1)
LigandBDBM223358
Substrate/Competitorn/a
Meas. Tech.BACE1 Cell-Free Assay
pH4.5±n/a
Temperature310.15±n/a K
IC50 1±n/a nM
Commentsextracted
Citation Brodney MABeck EMButler CRZhang LO'Neill BTBarreiro GLaChapelle EARogers BN 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides US Patent  US9315520 Publication Date 4/19/2016
More Info.:Get all data from this article,  Assay Method
 
Beta-secretase 1 (BACE1)
Name:Beta-secretase 1 (BACE1)
Synonyms:n/a
Type:Protein
Mol. Mass.:48152.67
Organism:Homo sapiens (Human)
Description:P56817-4
Residue:432
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL
WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI
KAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRP
VEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTA
AVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQ
HDDFADDISLLK
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  Blast E-value cutoff:
BDBM223358
n/a
NameBDBM223358
Synonyms:US9315520, Comparator 7 | US9605007, Comparator 7 | US9744173, Comparator 7
TypeSmall organic molecule
Emp. Form.C20H20ClFN4O2S
Mol. Mass.434.915
SMILES[H][C@]12CSC(N)=N[C@]1(CO[C@@H](C)C2)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F |c:5|
Structure
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