Reaction Details |
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Target | Isoform D of Beta-secretase 1 (BACE-I-432) |
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Ligand | BDBM223358 |
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Substrate/Competitor | n/a |
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Meas. Tech. | BACE1 Cell-Free Assay |
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pH | 4.5±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 1±n/a nM |
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Comments | extracted |
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Citation | Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides US Patent US9315520 Publication Date 4/19/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform D of Beta-secretase 1 (BACE-I-432) |
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Name: | Isoform D of Beta-secretase 1 (BACE-I-432) |
Synonyms: | BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE-I-432) | Beta-secretase 1 (BACE1) | KIAA1149 |
Type: | Protein |
Mol. Mass.: | 48152.67 |
Organism: | Homo sapiens (Human) |
Description: | P56817-4 |
Residue: | 432 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL
WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI
KAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRP
VEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTA
AVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQ
HDDFADDISLLK
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BDBM223358 |
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n/a |
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Name | BDBM223358 |
Synonyms: | US9315520, Comparator 7 | US9605007, Comparator 7 | US9744173, Comparator 7 |
Type | Small organic molecule |
Emp. Form. | C20H20ClFN4O2S |
Mol. Mass. | 434.915 |
SMILES | [H][C@]12CSC(N)=N[C@]1(CO[C@@H](C)C2)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F |c:5| |
Structure |
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