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TargetVascular endothelial growth factor receptor 2 [807-1356]
LigandBDBM225230
Substrate/Competitorn/a
Meas. Tech.HMT Assay
IC50>1.0e+4±n/a nM
Citation Qi, WZhao, KGu, JHuang, YWang, YZhang, HZhang, MZhang, JYu, ZLi, LTeng, LChuai, SZhang, CZhao, MChan, HChen, ZFang, DFei, QFeng, LFeng, LGao, YGe, HGe, XLi, GLingel, ALin, YLiu, YLuo, FShi, MWang, LWang, ZYu, YZeng, JZeng, CZhang, LZhang, QZhou, SOyang, CAtadja, PLi, E An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nat Chem Biol13:381-388 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vascular endothelial growth factor receptor 2 [807-1356]
Name:Vascular endothelial growth factor receptor 2 [807-1356]
Synonyms:FLK1 | KDR | Kinase insert domain receptor (KDR) | VEGFR2 | VGFR2_HUMAN
Type:Protein
Mol. Mass.:61508.67
Organism:Homo sapiens (Human)
Description:Human KDR truncation (807-1356 aa)
Residue:550
Sequence:
DPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVA
VKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLST
YLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDV
EEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICD
FGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPY
PGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQA
NAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQN
SKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMV
PSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPD
SGTTLSSPPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM225230
n/a
NameBDBM225230
Synonyms:EED226 | US11013745, Compound EED226
TypeSmall organic molecule
Emp. Form.C17H15N5O3S
Mol. Mass.369.398
SMILESCS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12
Structure
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