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TargetMitogen-activated protein kinase kinase kinase 8 (MAP3K8)
LigandBDBM225230
Substrate/Competitorn/a
Meas. Tech.HMT Assay
IC50>1.0e+4± 0 nM
Citation Qi WZhao KGu JHuang YWang YZhang HZhang MZhang JYu ZLi LTeng LChuai SZhang CZhao MChan HChen ZFang DFei QFeng LFeng LGao YGe HGe XLi GLingel ALin YLiu YLuo FShi MWang LWang ZYu YZeng JZeng CZhang LZhang QZhou SOyang CAtadja PLi E An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nat Chem Biol 13:381-388 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
Name:Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
Synonyms:n/a
Type:Protein
Mol. Mass.:42506.70
Organism:Homo sapiens (Human)
Description:Human MAP3K8 truncation (30-404 aa)
Residue:375
Sequence:
MENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFAN
HISNTAKHFYGQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAF
GKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEA
GEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLV
DFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVK
RYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALN
PPREDQPRCQSLDSA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM225230
n/a
NameBDBM225230
Synonyms:EED226
TypeSmall organic molecule
Emp. Form.C17H15N5O3S
Mol. Mass.369.398
SMILESCS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12
Structure
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