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TargetRho-associated protein kinase 2 [6-553]
LigandBDBM225230
Substrate/Competitorn/a
Meas. Tech.HMT Assay
IC50>1.0e+4±n/a nM
Citation Qi, WZhao, KGu, JHuang, YWang, YZhang, HZhang, MZhang, JYu, ZLi, LTeng, LChuai, SZhang, CZhao, MChan, HChen, ZFang, DFei, QFeng, LFeng, LGao, YGe, HGe, XLi, GLingel, ALin, YLiu, YLuo, FShi, MWang, LWang, ZYu, YZeng, JZeng, CZhang, LZhang, QZhou, SOyang, CAtadja, PLi, E An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nat Chem Biol13:381-388 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Rho-associated protein kinase 2 [6-553]
Name:Rho-associated protein kinase 2 [6-553]
Synonyms:KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2)
Type:Enzyme
Mol. Mass.:62870.88
Organism:Homo sapiens (Human)
Description:Human ROCK2 truncation (6-553 aa)
Residue:548
Sequence:
PTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKN
KNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSK
FEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD
VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMV
HCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSK
IMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIR
ETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDS
PSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELE
EEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKK
RNQNSQIS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM225230
n/a
NameBDBM225230
Synonyms:EED226 | US11013745, Compound EED226
TypeSmall organic molecule
Emp. Form.C17H15N5O3S
Mol. Mass.369.398
SMILESCS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12
Structure
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