Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPolycomb protein EED
LigandBDBM223984
Substrate/Competitorn/a
Meas. Tech.TR-FRET Binding Assay
pH7.5±0
Temperature298.15±0 K
Ki 1200±0.0 nM
Citation He, YSelvaraju, SCurtin, MLJakob, CGZhu, HComess, KMShaw, BThe, JLima-Fernandes, ESzewczyk, MMCheng, DKlinge, KLLi, HQPliushchev, MAlgire, MAMaag, DGuo, JDietrich, JPanchal, SCPetros, AMSweis, RFTorrent, MBigelow, LJSenisterra, GLi, FKennedy, SWu, QOsterling, DJLindley, DJGao, WGalasinski, SBarsyte-Lovejoy, DVedadi, MBuchanan, FGArrowsmith, CHChiang, GGSun, CPappano, WN The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol13:389-395 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polycomb protein EED
Name:Polycomb protein EED
Synonyms:EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:Protein
Mol. Mass.:50201.68
Organism:Homo sapiens (Human)
Description:O75530
Residue:441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM223984
n/a
NameBDBM223984
Synonyms:rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine (1)
TypeSmall organic molecule
Emp. Form.C23H29N3O
Mol. Mass.363.4959
SMILESCOc1ccccc1CN1C[C@@H]([C@H](C1)c1cn(C)c2ccccc12)N(C)C |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: