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TargetCarbonic anhydrase 2
LigandBDBM224004
Substrate/Competitorn/a
Meas. Tech.Fluorescence-Based CA II Binding Assay
pH7±0
Temperature298.15±0 K
IC50 139± 71 nM
Citation Teruya KRankin GMChrysanthopoulos PKTonissen KFPoulsen SA Characterisation of Photoaffinity-Based Chemical Probes by Fluorescence Imaging and Native-State Mass Spectrometry. Chembiochem 18:739-754 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 2
Name:Carbonic anhydrases; II & IX
Synonyms:CA-II | CA2 | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:Enzyme
Mol. Mass.:29250.71
Organism:Homo sapiens (Human)
Description:P00918
Residue:260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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  Blast E-value cutoff:
BDBM224004
n/a
NameBDBM224004
Synonyms:N-{(1S)-2-[1-(4-Benzoylphenyl)-1H-1,2,3-triazol-4-yl]-1-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)carbamoyl]ethyl}-4,7,10,13,16-pentaoxanonadec-18-ynamide (11)
TypeSmall organic molecule
Emp. Form.C34H40N8O10S2
Mol. Mass.784.859
SMILESNS(=O)(=O)c1nnc(NC(=O)[C@H](Cc2cn(nn2)-c2ccc(cc2)C(=O)c2ccccc2)NC(=O)CCOCCOCCOCCOCCOCC#C)s1 |r|
Structure
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