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TargetcAMP-dependent protein kinase catalytic subunit alpha
LigandBDBM224010
Substrate/Competitorn/a
Meas. Tech.Equilibrium Binding/Displacement Assay with Fluorescence Anisotropy
pH7.5±n/a
Kd 52±1 nM
Commentsextracted
Citation Kestav, KViht, KKonovalov, AEnkvist, EUri, ALavogina, D Slowly on, Slowly off: Bisubstrate-Analogue Conjugates of 5-Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin. Chembiochem18:790-798 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
cAMP-dependent protein kinase catalytic subunit alpha
Name:cAMP-dependent protein kinase catalytic subunit alpha
Synonyms:KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit
Type:Enzyme Catalytic Subunit
Mol. Mass.:40598.73
Organism:Homo sapiens (Human)
Description:n/a
Residue:351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML
VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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  Blast E-value cutoff:
BDBM224010
n/a
NameBDBM224010
Synonyms:ARC-3384
TypeSmall organic molecule
Emp. Form.C85H125N26O22
Mol. Mass.1863.0614
SMILESCC(O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@H](CCCCNC(=O)C[C@@H](NC(=O)CCCCCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12)C([O-])=O)NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@H](C)[NH3+])C(=O)N[C@@H](C)C(=O)N[C@H](CCCCNC(=O)c1ccc(c(c1)C(O)=O)-c1c2ccc(cc2oc2cc(ccc12)=[N+](C)C)N(C)C)C(N)=O |r,wU:71.81,16.23,3.3,48.47,50.55,wD:27.70,82.86,7.12,88.91,93.95,36.36,51.51,53.54,(30.59,-14.16,;31.92,-14.93,;33.25,-14.16,;31.92,-16.47,;30.59,-17.24,;29.25,-16.47,;29.25,-14.93,;27.92,-17.24,;27.92,-18.78,;26.59,-19.55,;26.59,-21.09,;27.92,-21.86,;25.25,-21.86,;26.59,-16.47,;25.25,-17.24,;25.25,-18.78,;23.92,-16.47,;23.92,-14.93,;22.58,-14.16,;22.58,-12.62,;21.25,-11.85,;21.25,-10.31,;22.58,-9.54,;19.92,-9.54,;22.58,-17.24,;21.25,-16.47,;21.25,-14.93,;19.92,-17.24,;19.92,-18.78,;18.58,-19.55,;18.58,-21.09,;17.25,-21.86,;17.25,-23.4,;15.92,-24.17,;14.58,-23.4,;15.92,-25.71,;14.58,-26.48,;13.25,-25.71,;11.91,-26.48,;11.91,-28.02,;10.58,-25.71,;9.25,-26.48,;7.91,-25.71,;6.58,-26.48,;5.25,-25.71,;3.91,-26.48,;3.91,-33.15,;2.58,-33.92,;5.25,-33.92,;6.54,-33.08,;7.73,-34.05,;7.18,-35.49,;8.02,-36.78,;5.64,-35.41,;4.68,-36.61,;9.22,-33.66,;9.77,-32.22,;11.31,-32.3,;11.71,-33.79,;13.08,-34.48,;14.37,-33.65,;13.16,-36.02,;11.87,-36.86,;10.5,-36.16,;10.42,-34.62,;14.58,-28.02,;15.92,-28.79,;13.25,-28.79,;18.58,-16.47,;17.25,-17.24,;17.25,-18.78,;15.92,-16.47,;15.92,-14.93,;14.58,-14.16,;14.58,-12.62,;13.25,-11.85,;13.25,-10.31,;14.58,-9.54,;11.91,-9.54,;14.58,-17.24,;13.25,-16.47,;13.25,-14.93,;11.91,-17.24,;11.91,-18.78,;10.58,-16.47,;33.25,-17.24,;33.25,-18.78,;34.59,-16.47,;35.92,-17.24,;35.92,-18.78,;37.25,-16.47,;37.25,-14.93,;38.59,-17.24,;39.92,-16.47,;39.92,-14.93,;38.59,-14.16,;38.59,-12.62,;37.25,-11.85,;37.25,-10.31,;35.92,-9.54,;34.59,-10.31,;35.92,-8,;34.59,-7.23,;34.59,-5.69,;35.92,-4.92,;37.25,-5.69,;37.25,-7.23,;38.74,-5.29,;39.14,-3.8,;39.83,-6.38,;35.92,-3.38,;34.59,-2.61,;33.25,-3.38,;31.92,-2.61,;31.92,-1.07,;33.25,-.3,;34.59,-1.07,;35.92,-.3,;37.25,-1.07,;38.59,-.3,;39.92,-1.07,;39.92,-2.61,;38.59,-3.38,;37.25,-2.61,;41.26,-.3,;41.26,1.24,;42.59,-1.07,;30.59,-.3,;30.59,1.24,;29.25,-1.07,;41.26,-17.24,;42.59,-16.47,;41.26,-18.78,)|
Structure
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