Ki Summary

Reaction Details

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Target

Mas-related G-protein coupled receptor member X2

Ligand

BDBM85324

Substrate/Competitor

n/a

Meas. Tech.

Intracellular Calcium Mobilization Assay

7.4±0

Temperature

303.15±0 K

EC50

4.2e+2±1.3e+2 nM

Citation

Lansu, K; Karpiak, J; Liu, J; Huang, XP; McCorvy, JD; Kroeze, WK; Che, T; Nagase, H; Carroll, FI; Jin, J; Shoichet, BK; Roth, BL In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol13:529-536 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mas-related G-protein coupled receptor member X2

Name:

Mas-related G-protein coupled receptor member X2

Synonyms:

MRGPRX2 | MRGX2 | MRGX2_HUMAN | Mas-related G protein-coupled receptor X2 (MRGPRX2) | Mas-related G-protein coupled receptor member X2

Type:

GPCR

Mol. Mass.:

37104.79

Organism:

Homo sapiens (Human)

Description:

Q96LB1

Residue:

330

Sequence:

MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMR
RNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSML
STVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWC
QTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFG
IQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLAL
QRALQDIAEVDHSEGCFRQGTPEMSRSSLV

BDBM85324

n/a

Name

BDBM85324

Synonyms:

CAS_186901-48-4 | CORTISTATIN-14 | cortistatin14

Type

Small organic molecule

Emp. Form.

C81H113N19O19S2

Mol. Mass.

1721.01

SMILES

C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@@H]1CCCN1 |r|

Structure