Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMas-related G-protein coupled receptor member X2
LigandBDBM50290872
Substrate/Competitorn/a
Meas. Tech.Intracellular Calcium Mobilization Assay
pH7.4±0
Temperature303.15±0 K
EC50 6.5e+2±9e+1 nM
Citation Lansu, K; Karpiak, J; Liu, J; Huang, XP; McCorvy, JD; Kroeze, WK; Che, T; Nagase, H; Carroll, FI; Jin, J; Shoichet, BK; Roth, BL In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol13:529-536 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mas-related G-protein coupled receptor member X2
Name:Mas-related G-protein coupled receptor member X2
Synonyms:MRGPRX2 | MRGX2 | MRGX2_HUMAN | Mas-related G protein-coupled receptor X2 (MRGPRX2) | Mas-related G-protein coupled receptor member X2
Type:GPCR
Mol. Mass.:37104.79
Organism:Homo sapiens (Human)
Description:Q96LB1
Residue:330
Sequence:
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMR
RNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSML
STVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWC
QTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFG
IQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLAL
QRALQDIAEVDHSEGCFRQGTPEMSRSSLV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50290872
n/a
NameBDBM50290872
Synonyms:(-)-rel-3-((4aR,12aS)-2-methyl-1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridin-4a-yl)phenol | 3-((4aS,12aR)-2-Methyl-1,3,4,5,12,12a-hexahydro-2H-2,6-diaza-naphthacen-4a-yl)-phenol | CHEMBL327745 | SB-213698 | TAN-67 | Tan-67 (racemic)
TypeSmall organic molecule
Emp. Form.C23H24N2O
Mol. Mass.344.4495
SMILESCN1CC[C@@]2(Cc3nc4ccccc4cc3C[C@H]2C1)c1cccc(O)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: