Ki Summary

Reaction Details

Report a problem with these data

Target

Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)

Ligand

BDBM224802

Substrate/Competitor

n/a

Meas. Tech.

Scintillation Proximity Assay

Temperature

298.15±n/a K

IC50

7±n/a nM

Comments

extracted

Citation

Heine, N; Eickmeier, C; Ferrera, M; Giovannini, R; Rosenbrock, H; Schaenzle, G 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders US Patent US9328120 Publication Date 5/3/2016

More Info.:

Get all data from this article, Assay Method

Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)

Name:

Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)

Synonyms:

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2

Type:

Protein

Mol. Mass.:

61702.98

Organism:

Homo sapiens (Human)

Description:

O76083-2

Residue:

533

Sequence:

MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA

BDBM224802

n/a

Name

BDBM224802

Synonyms:

US9328120, 32

Type

Small organic molecule

Emp. Form.

C20H21F2N5O

Mol. Mass.

385.4104

SMILES

FC1(F)CCC(CC1)n1ncc2c1nc([nH]c2=O)[C@@H]1CC[C@H]1c1ccccn1 |r|

Structure