| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) |
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| Ligand | BDBM224803 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Scintillation Proximity Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 388±n/a nM |
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| Comments | extracted |
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| Citation |  Heine, N; Eickmeier, C; Ferrera, M; Giovannini, R; Rosenbrock, H; Schaenzle, G 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders US Patent US9328120 Publication Date 5/3/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) |
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| Name: | Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) |
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| Synonyms: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2 |
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| Type: | Protein |
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| Mol. Mass.: | 61702.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O76083-2 |
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| Residue: | 533 |
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| Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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| BDBM224803 |
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| n/a |
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| Name | BDBM224803 |
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| Synonyms: | US9328120, 33 (enantiomer 1) | US9328120, 34 (enantiomer 2) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21F2N5O |
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| Mol. Mass. | 385.4104 |
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| SMILES | FC1(F)CCC(CC1)n1ncc2c1nc([nH]c2=O)C1CCC1c1ccccn1 |
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| Structure | 
|
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