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TargetIsoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
LigandBDBM224797
Substrate/Competitorn/a
Meas. Tech.Scintillation Proximity Assay
Temperature298.15±n/a K
IC50 360±n/a nM
Commentsextracted
Citation Heine, NEickmeier, CFerrera, MGiovannini, RRosenbrock, HSchaenzle, G 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders US Patent US9328120 Publication Date 5/3/2016
More Info.:Get all data from this article,  Assay Method
 
Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Name:Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2)
Synonyms:High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A (PDE9A2) | Phosphodiesterase 9A2
Type:Protein
Mol. Mass.:61702.98
Organism:Homo sapiens (Human)
Description:O76083-2
Residue:533
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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  Blast E-value cutoff:
BDBM224797
n/a
NameBDBM224797
Synonyms:US9328120, 27 (enantiomer 1) | US9328120, 28 (enantiomer 2)
TypeSmall organic molecule
Emp. Form.C19H17N7O
Mol. Mass.359.3846
SMILESCc1ccncc1-n1ncc2c1nc([nH]c2=O)C1CCC1c1ncccn1
Structure
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